Abcam, ab122451, Anti-CCDC75 antibody

Size: 100µL
Rabbit Polyclonal CCDC75 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GPATCH11 aa 100-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GPATCH11 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q8N954

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CCDC75 also known as coiled-coil domain containing 75 is a protein involved in cellular mechanics. Structurally it has a molecular mass of approximately 71 kDa and is expressed in various tissues including the brain and testis. CCDC75 plays a role in the formation of protein complexes within the cell. This protein has a structural composition that enables it to facilitate interactions with other proteins contributing to cellular processes that require spatial organization.
Biological function summary
CCDC75 interacts with multiple cellular structures contributing to the regulation of mitosis. It often functions as part of larger protein complexes such as those associated with the centrosome. These complexes are critical during cell division ensuring proper chromosome segregation. CCDC75's involvement in centrosome function indicates its importance in maintaining genomic stability during cell replication.
Pathways
CCDC75 interacts in the regulation of the cell cycle particularly in the mitotic spindle assembly pathway. It is associated with proteins like CENP-E and CENP-N which are required for accurate chromosome movement. The proper function of CCDC75 in these pathways helps maintain cell integrity and prevents abnormalities during cell division important for healthy cell reproduction.
CCDC75 associates with conditions related to aberrant cell division like cancer and certain types of infertility. Mistakes in its function can connect to genomic instability seen in cancer where cells divide uncontrollably. Moreover CCDC75 interactions with proteins like CENP-Y can influence its stability in pathways that when disrupted may contribute to the development of these disorders. Studies regularly examine its role to understand how misregulation contributes to such diseases.