Abcam, ab122485, Anti-FCHSD2 antibody

Size: 100µL
Rabbit Polyclonal FCHSD2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FCHSD2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FCHSD2. The exact immunogen used to generate this antibody is proprietary information.O94868

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FCHSD2 also known as F-BAR and double SH3 domain-containing protein 2 is a protein that mechanically regulates membrane dynamics and cytoskeletal arrangements. It has a molecular mass of approximately 74 kDa and is expressed in various tissues with high expression levels in the brain and heart. FCHSD2 is an adapter protein that is involved in shaping membrane curvature and plays a role in the endocytosis process by interacting with membranes.
Biological function summary
FCHSD2 connects cytoskeletal networks with membrane structures influencing cellular shape and movement. It is part of a multiprotein complex that modulates actin filament organization. FCHSD2 interacts with other proteins that participate in similar structural functions facilitating the coordination of cellular architecture. This protein contributes to maintaining cellular integrity by responding to signals that require cytoskeletal rearrangement.
Pathways
FCHSD2 participates in the endocytosis pathway a critical process for molecular transport across cell membranes. It interacts with proteins like dynamin which is essential for membrane scission events. The protein also plays a role in actin cytoskeleton reorganization alongside others such as cortactin contributing to cellular mobility and changes in cell shape. FCHSD2 helps ensure these processes function properly by linking them to membrane dynamics.
Aberrations in FCHSD2 function associate with neurological conditions and cardiac disorders. In the brain altered FCHSD2 expression may contribute to neurodegenerative diseases because of its role in regulating neuronal membrane dynamics and cytoskeletal interactions. In cardiology FCHSD2 has connections to proteins such as filamin and disruptions in these interactions can affect heart function possibly leading to cardiomyopathies. Understanding FCHSD2's involvement could be key in developing therapeutic approaches for these diseases.