Abcam, ab122523, Anti-PRHOXNB antibody

Size: 100µL
Rabbit Polyclonal PRHOXNB antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human URAD aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human URAD aa 1-100. The exact immunogen used to generate this antibody is proprietary information.A6NGE7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PRHOXNB also known as paired related homeobox protein NB is a cellular protein functioning in transcriptional regulation. It has a molecular mass of approximately 32 kDa. The expression of PRHOXNB occurs predominantly in the central nervous system and some peripheral tissues. It serves an essential role in the transcription regulation by interacting with specific DNA sequences influencing gene expression.
Biological function summary
PRHOXNB influences neuronal differentiation and development. It functions as part of a larger transcriptional complex. PRHOXNB contributes to the determination of cell fate during neural development. By interacting with other transcription factors it modulates the activity of genes involved in neural cell differentiation promoting normal brain development and function.
Pathways
PRHOXNB is involved in the Wnt signaling pathway and neural development pathways. Its interactions within the Wnt signaling pathway help regulate neural patterning and synaptogenesis. PRHOXNB often cooperates with proteins like β-catenin within these pathways contributing to the regulation of target gene expression. These interactions ensure proper neural tissue development and maintenance.
PRHOXNB has been linked to neurodevelopmental disorders and certain types of cancer. Altered expression or mutations in PRHOXNB may contribute to neural developmental issues such as autism spectrum disorders. Additionally its abnormal activity has been observed in certain cancers where it might interact with proteins like p53 impacting cell cycle regulation and leading to tumorigenesis.