Abcam, ab122548, Anti-PPTC7 antibody

Size: 100µL
Rabbit Polyclonal PPTC7 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Rat, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PPTC7 aa 100-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PPTC7 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q8NI37

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PPTC7 also known as protein phosphatase targeting orey complex 7 functions as a serine/threonine phosphatase. It has a molecular mass of approximately 33 kDa. The protein is expressed in various tissues with high expression in the liver and skeletal muscle. PPTC7 plays a role in mitochondrial protein import dephosphorylating transporter components to facilitate their entry into mitochondria.
Biological function summary
The protein plays a role in mitochondrial health and energy metabolism. By dephosphorylating specific targets it maintains the proper function of mitochondria essential for energy production. The protein is not part of a larger complex but works with components within the mitochondria to support their operations. PPTC7 ensures that the mitochondrial proteins are in the right phosphorylation state which is important for cellular energy needs.
Pathways
PPTC7 interacts with cellular energy metabolic pathways particularly those involving oxidative phosphorylation. The protein interacts with TOM-TIM complexes essential for protein translocation into mitochondria. These interactions affect mitochondrial import regulation ensuring cells efficiently perform energy production processes.
Dysfunction in PPTC7 activity correlates with metabolic disorders and mitochondrial diseases. Aberrant function of this protein can lead to defects in energy metabolism contributing to conditions like mitochondrial myopathy. PPTC7 through its role in mitochondria maintenance influences disorders where metabolism is affected similar to other mitochondrial-involved proteins like PINK1 or MFN2 which are important in neurodegenerative diseases.