Abcam, ab122789, Anti-SBNO1 antibody

Size: 100µL
Rabbit Polyclonal SBNO1 antibody. Suitable for IHC-P, ICC, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SBNO1 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SBNO1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.A3KN83

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SBNO1 also known as Strawberry Notch Homolog 1 is a DNA-binding protein involved in transcriptional regulation. Creatively referred to by researchers as SBNO1 this protein has a molecular mass of about 84 kDa. It is expressed in various tissues with significant levels in immune cells and organs like the spleen and lymph nodes. SBNO1 locates both in the nucleus and the cytoplasm where it performs its mechanical roles related to gene expression.
Biological function summary
SBNO1 functions as a transcriptional co-regulator and plays a role in inflammatory response. It does not form part of a persistent complex but interacts dynamically with other molecules during gene regulation processes. Researchers have observed that SBNO1 modulates the signaling of pro-inflammatory cytokines influencing the immune system significantly. By affecting the transcription of particular genes SBNO1 contributes to cellular responses to external stimuli.
Pathways
SBNO1 interacts significantly with the Toll-like receptor signaling pathway affecting immune response regulation. Additionally it plays a role in the NF-kappa B signaling pathway where it assists in modulating inflammation and immune functions. SBNO1 works alongside proteins such as MYD88 and IRAK4 influencing the cascade of events leading to the activation of transcription factors responsible for inflammatory gene expression.
SBNO1 plays a role in conditions such as autoimmune diseases and chronic inflammation. Its regulation of cytokine signaling links SBNO1 to rheumatoid arthritis where it potentially affects disease severity. SBNO1's interaction with key proteins like IL-6 and TNF-alpha further highlights its involvement in pathological inflammatory processes. Understanding SBNO1's function could provide insights into therapeutic targets for managing inflammatory disorders.