Abcam, ab122800, Anti-Adropin antibody

Size: 100µL
Rabbit Polyclonal Adropin antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ENHO.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ENHO. The exact immunogen used to generate this antibody is proprietary information.Q6UWT2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Adropin is a secreted peptide hormone also known as Energy Homeostasis Associated (ENHO) gene product. This protein has a mass of approximately 4.5 kDa and is primarily expressed in the liver and brain but also in the pancreas and various peripheral tissues. Adropin plays a role in regulating metabolic homeostasis influencing lipid metabolism and glucose levels through its action. It facilitates communication within cells to maintain energy balance and research shows its involvement in modulating insulin sensitivity.
Biological function summary
Adropin influences glucose homeostasis and fatty acid metabolism. It does not form part of a larger complex but functions as a solitary signaling molecule. The protein impacts cellular processes by increasing glucose oxidation and reducing fatty acid oxidation contributing to energy balance. Studies have demonstrated its role in influencing cardiovascular functions and central nervous systems processes which link it to various metabolic conditions.
Pathways
Adropin is involved in the regulation of energy balance through the insulin signaling pathway and the AMPK pathway. Both pathways help manage glucose uptake and energy expenditure. In the insulin signaling pathway adropin works alongside other proteins like PPARγ and GLUT4 to control glucose levels. Adropin's role in the AMPK pathway relates to cellular energy charge and helps maintain metabolic health by modulating lipid and glucose metabolism.
Adropin has potential links to obesity and type 2 diabetes where it might contribute to pathophysiologies. Its reduced levels are often observed in patients with these conditions. The association to disorders involves interaction with proteins such as insulin receptor substrate (IRS) and adiponectin which mediate metabolic responses affecting glucose and lipid homeostasis. Understanding adropin's actions in these contexts could assist in the development of novel therapeutic strategies targeting metabolic disorders.