Abcam, ab122903, Anti-Netrin 1 antibody

Size: 50µg
Goat Polyclonal Netrin 1 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human NTN1 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NTN1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.O95631

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Netrin-1 also known as NTN1 or Netrin-1 protein is a guidance cue important for cell migrations. It falls under the netrin proteins and has an approximate mass of 70 kDa. This protein is mainly expressed in the central nervous system especially during development but also appears in certain developing tissues and organs. Netrin-1 interacts with various receptors influencing axon guidance and cell motility.
Biological function summary
Netrin proteins play key roles in directing neuronal and vascular development. Netrin-1 influences axon pathfinding by attracting or repelling growth cones and also participates in angiogenesis. It does not usually form a stable complex but functions through interactions with distinct receptor types like DCC Neogenin and UNC5 homologue proteins. These interactions determine the direction of cellular movement and position within tissues.
Pathways
Netrin-1 integrates within signaling pathways such as the MAPK and PI3K/AKT pathways. It influences neuron migration and blood vessel formation within these pathways. Netrin receptors like DCC and UNC5B are important in transducing netrin-1 signals. These pathways involve intricate signaling cascades modulating cell survival growth and trajectory establishing netrin-1 as significant in neurodevelopmental processes.
Researchers link netrin-1 to neurodegenerative diseases and cancer metastasis. Abnormal levels of netrin-1 can associate with disorders like Alzheimer's disease and various cancers. In cancer netrin-1 interaction with its receptors might influence tumour cell survival and invasion resembling mechanisms found in neuronal cells. Understanding the role of netrin-1 in these conditions could uncover valuable therapeutic targets potentially involving DCC and UNC5 homologues among other associated molecules.