Abcam, ab123930, Anti-CCM2 antibody [OTI2E4]

Size: 100µL
Mouse Monoclonal CCM2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, African green monkey samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CCM2.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI2E4,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human, African green monkey,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CCM2.Q9BSQ5

Product details:
Clone OTI2E4 (formerly 2E4).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant by affinity chromatography., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CCM2 also known as Malcavernin functions in the stability of cell-cell junctions in blood vessels. It has an approximate molecular mass of 50 kDa. The protein is largely expressed in vascular endothelial cells which are cells lining the inside of the blood vessels. CCM2 forms part of a protein scaffold that guides the cellular responses to mechanical stress maintaining vascular integrity.
Biological function summary
It interacts with several proteins to form a well-coordinated complex including KRIT1 and CCM3 contributing to the maintenance of vascular structure. The CCM2 protein is essential for regulating the cellular pathways that respond to oxidative stress. It facilitates actin cytoskeleton organization and modulates endothelial barrier function providing a structural basis for cellular processes involving vascular homeostasis.
Pathways
The protein is an important component in the RhoA signaling and MAPK pathways which influence cellular shape and proliferation. Within these pathways CCM2 influences various proteins including ROCK and MEK to execute its function. It ensures proper signal transduction that is necessary for maintaining cellular responses to environmental changes which can be important for normal vascular function.
CCM2 mutations associate closely with cerebral cavernous malformations (CCM) which trigger abnormal blood vessel formation in the brain that leads to seizures or stroke. During this condition the protein's interaction with KRIT1 exhibits significant influence since defects in the gene encoding CCM2 or KRIT1 can lead to disease phenotypes. Researchers study these interactions to better understand and develop therapeutics for vascular malformation-related diseases.