Abcam, ab124272, Anti-GPCR GPR43 antibody

Size: 50µL
Rabbit Polyclonal GPCR GPR43 antibody. Suitable for ICC/IF, IHC-P and reacts with African green monkey, Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human FFAR2 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, African green monkey,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FFAR2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.O15552

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
G protein-coupled receptor 43 (GPR43) also known as free fatty acid receptor 2 (FFAR2) is a receptor that plays important roles in cellular communication and function. As a GPCR it transduces extracellular signals through interactions with G proteins. The receptor has a mass of approximately 35 kDa. GPR43 is expressed in a variety of tissues with significant expression in cells of the immune system including neutrophils monocytes and dendritic cells as well as in adipose tissue and the gut.
Biological function summary
GPR43 plays a role in modulating inflammatory responses and energy metabolism. It is known to bind short-chain fatty acids (SCFAs) such as acetate and propionate produced through dietary fiber fermentation by gut microbiota. GPR43 signaling can influence the immune response by promoting anti-inflammatory pathways and regulating the production of cytokines. It does not form part of a complex and functions primarily as a standalone receptor within these biological systems.
Pathways
GPR43 signaling influences the inflammatory and metabolic pathways. It is involved in mediating anti-inflammatory effects through the inhibition of pro-inflammatory cytokine production and NF-kB signaling. GPR43 also participates in the regulation of lipid metabolism pathways by enhancing adipocyte differentiation and insulin sensitivity. These interactions involve other receptors and proteins like GPR41 which shares similar agonists and functions.
GPR43 has been implicated in inflammatory bowel disease (IBD) and obesity-related conditions. Altered GPR43 expression and signaling can contribute to the pathogenesis of IBD by affecting gut microbiome composition and inflammatory processes. In obesity GPR43 influences metabolic health through its role in energy homeostasis and adipose tissue function. The receptor's interaction with proteins like GPR41 in these disorders emphasizes its importance in maintaining physiological balance.