Abcam, ab124737, Anti-Kininogen 1 antibody [EPR6097]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Kininogen antibody. Suitable for IHC-P, IP, ELISA, WB and reacts with Human, Recombinant fragment samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6097,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, IP, WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody detects three isoforms of Kininogen 1: full length (120 kDa), light chain (56 kDa), and cleavage form (45 kDa).

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Kininogen 1 often referred to as kininogen-1 or high molecular weight kininogen (HMWK) is a significant protein in the body with a mass of approximately 120 kDa. It is primarily expressed in the liver and secreted into plasma. Kininogen 1 acts as a precursor for kinins vital for various physiological processes. The cleavage of kininogen releases bradykinin a potent vasodilator which suggests roles in blood pressure regulation and inflammation.
Biological function summary
Kininogen 1 influences processes such as blood coagulation and inflammation. It is a part of the kallikrein-kinin system where it helps in generating kallidin and bradykinin. These peptides play important roles in vasodilation increasing vascular permeability and pain mechanisms. Kininogen 1 serves as a cofactor for the activation of coagulation factor XII linking coagulation and inflammation pathways.
Pathways
Kininogen 1 plays a critical role in the kallikrein-kinin and contact activation pathways. Within the kallikrein-kinin pathway it works along with the kallikrein enzyme to produce kinins. In the contact activation pathway it associates with prekallikrein and factor XII influencing both coagulation and inflammatory responses in the body.
Kininogen 1 is associated with hereditary angioedema and cardiovascular disease. Its role in bradykinin generation relates to the excessive swelling seen in hereditary angioedema due to bradykinin buildup. Additionally its interactions with coagulation factors such as factor XII connect it to cardiovascular disorders where improper coagulation regulation can lead to pathological blood clotting.