Abcam, ab124783, Anti-RAE1 antibody [EPR6923]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RAE1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6923,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RAE1 also known as Regulator of Chromosome Condensation 1 is a protein with a molecular mass of approximately 44 kDa. This protein primarily binds to mRNA facilitating its export from the nucleus to the cytoplasm. Expressed abundantly in multiple tissues RAE1 plays an integral role in the cellular machinery that governs mRNA transport. It directly interacts with the nuclear pore complex exhibiting specific binding with the nucleoporins a component essential for mRNA export.
Biological function summary
RAE1 functions as a part of the mRNA export machinery ensuring accurate and efficient mRNA transfer to the cytoplasm. It forms a complex with Nup98 an important player in nucleocytoplasmic transport. This interaction highlights its significance in mRNA processing and maintaining RNA stability within cells. By collaborating with other export factors RAE1 supports mRNA maturation processes that are critical for subsequent translation into proteins.
Pathways
RAE1 takes an active role in the nucleocytoplasmic transport pathway and influences the gene expression regulation pathway. Both these pathways are vital for converting genetic information into functional proteins. RAE1 also collaborates with proteins such as Nup98 and CRM1 which further illustrates its importance in the complex network of cellular transport systems. These pathways integrate signals that ensure the appropriate expression and localization of mRNA thereby forming an essential link between transcription and translation.
Abnormalities in RAE1 function can relate to cancer and neurological disorders. Disruptions in mRNA transport where RAE1 is a critical component have been observed in several cancer types highlighting its relationship with oncogenic processes. Additionally improper interaction between RAE1 and Nup98 may contribute to conditions affecting neural function suggesting potential connections with neurodegenerative diseases. Understanding RAE1's role in these pathologies may provide insights into developing new therapeutic strategies.