Abcam, ab124927, Anti-ZNF217 antibody [EPR6362]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ZNF217 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6362,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF217 also known as Zinc Finger Protein 217 functions mechanically as a transcriptional repressor and is part of the Krüppel-like C2H2 zinc finger proteins. It has a molecular mass of approximately 121 kDa. ZNF217 is primarily expressed in tissues such as the brain prostate and breast. It binds to specific DNA sequences and regulates gene expression often altering cellular differentiation and proliferation by repressing or activating target genes.
Biological function summary
ZNF217 plays a significant role in cellular processes such as cell growth and survival. The protein associates with a multiprotein complex that includes CoREST histone deacetylases and lysine-specific demethylases. This association impacts chromatin remodeling and transcriptional control. ZNF217's influence on gene expression affects important cellular functions including differentiation and apoptosis by modifying chromatin structure and subsequently regulating gene transcription levels.
Pathways
This transcriptional regulator influences two critical signaling pathways the TGF-beta and PI3K/AKT pathways both of which are essential for cellular growth and survival. ZNF217 interacts with proteins like SMAD2 which is a part of the TGF-beta pathway affecting cellular proliferation and differentiation processes. Through these connections ZNF217 contributes to the modulation of signaling cascades that control various aspects of cell behavior often with direct impacts on cellular homeostasis and pathology.
Altered expression of ZNF217 associates with several cancers including breast cancer and ovarian cancer. Overexpression of ZNF217 correlates with the progression and poor prognosis of these cancers. This zinc finger protein interacts with MYC a well-known regulator involved in many cancers promoting cellular proliferation and survival in oncogenic contexts. These interactions illustrate ZNF217's role in tumorigenesis and highlight its potential as a target for therapeutic interventions in cancer treatment.