Abcam, ab126181, Anti-ATP5L antibody

Size: 50µL
Rabbit Polyclonal ATP5L antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ATP5MG aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ATP5MG aa 1-100. The exact immunogen used to generate this antibody is proprietary information.O75964

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ATP5L also known as ATP synthase subunit f is a component of the mitochondrial ATP synthase complex. This protein is involved in the production of ATP the primary energy carrier within cells. The precise mass of human ATP5L is approximately 16 kDa. ATP5L is highly expressed in tissues with high energy demand such as the heart liver and skeletal muscle indicating its role in energy metabolism and mitochondrial functionality.
Biological function summary
ATP5L plays an essential part in ATP synthesis by facilitating the proton translocation across the mitochondrial membrane. It is a component of the F1F0 ATP synthase complex also known as Complex V of the electron transport chain. This complex synthesizes ATP from ADP and inorganic phosphate during oxidative phosphorylation an important process for cellular energy supply. Through its involvement in this complex ATP5L contributes to maintaining adequate levels of ATP within the cell.
Pathways
ATP5L acts within the oxidative phosphorylation and cellular respiration pathways. It collaborates with closely associated proteins like ATP5O and ATP5B in the energy production process. These pathways critically support cellular energy homeostasis and provide the energy required for various metabolic processes. ATP5L's function is thereby directly linked to the electron transport chain's efficient operation enabling the conversion of nutrient-derived energy into a usable cellular form.
Dysfunction in ATP5L has implications in metabolic-related disorders such as mitochondrial diseases and energy metabolism imbalances. ATP5L mutations or dysregulation can contribute to conditions like mitochondrial encephalomyopathy which affects the nervous system and muscles. Additionally the interaction of ATP5L with related proteins such as ATP5A1 can influence cardiac diseases where energy deficiencies lead to compromised heart function. Understanding these links offers insight into potential therapeutic targets for disorders related to energy metabolism.