Abcam, ab126331, Anti-SCRT1 antibody

Size: 100µL
Rabbit Polyclonal SCRT1 antibody. Suitable for IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Transcriptional repressor scratch 1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Transcriptional repressor scratch 1. The exact immunogen used to generate this antibody is proprietary information.Q9BWW7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCRT1 also known as Scratch family transcriptional repressor 1 is a zinc finger transcription factor with a molecular weight of approximately 40 kDa. It is expressed in the central nervous system particularly in areas associated with neuronal development and differentiation. The SCRT1 protein binds to specific DNA sequences modulating gene expression by repressing target genes involved in cellular processes.
Biological function summary
SCRT1 plays a role in regulating neuronal differentiation and migration during development. It is not part of a large protein complex but interacts with other transcription factors to modify transcriptional activities. SCRT1 achieves its biological function by repressing genes essential for the maintenance of neural progenitors thereby facilitating the transition to mature neuronal phenotypes.
Pathways
SCRT1 influences neural development pathways interacting with Notch signaling and other developmental pathways. Within these frameworks SCRT1 negatively regulates the expression of genes downstream of proteins like Hes1 and Ascl1 which are important for maintaining neuroprogenitor characteristics and promoting neuronal maturation. This tight regulation ensures proper neuronal development by controlling the balance between neural cell proliferation and differentiation.
Mutations or dysregulation of SCRT1 have connections to neurodevelopmental disorders such as intellectual disabilities and autism spectrum disorders. Additionally SCRT1 interacts with proteins like REST which is implicated in the pathogenesis of such conditions. Altered SCRT1 activity may contribute to the failure of neuronal cells to correctly differentiate leading to the manifestations seen in these disorders.