Abcam, ab126338, Anti-RPP25 antibody

Size: 100µL
Rabbit Polyclonal RPP25 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Ribonuclease P protein subunit p25.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Ribonuclease P protein subunit p25. The exact immunogen used to generate this antibody is proprietary information.Q9BUL9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPP25 also known as Ribonuclease P/MRP 25 kDa subunit is a protein with an approximate mass of 25 kDa. It plays an important mechanical role in the cellular environment as part of the ribonuclease P and ribonuclease MRP complexes. These complexes are key for the cleavage of precursor RNAs. RPP25 is expressed broadly with presence noted in most human tissues which suggests its functional importance in various cellular processes.
Biological function summary
RPP25 functions as an essential part of ribonucleoprotein complexes that include ribonuclease P and ribonuclease MRP. These complexes are involved in the maturation of tRNA and rRNA respectively highlighting RPP25's role in RNA processing. As a component of these ribonucleases RPP25 works alongside other proteins such as RPP30 and POP1 helping to perform critical RNA processing tasks within the cell.
Pathways
The involvement of RPP25 in the RNA processing pathway demonstrates its importance alongside other proteins. In particular it takes part in the maturation of tRNA within the tRNA biosynthesis pathway. This process is critical for proper translation and protein synthesis. RPP25 also interacts within the rRNA processing pathway where it contributes to the generation of mature ribosomal RNA a necessity for the formation of functional ribosomes.
Mutations or dysregulation of RPP25 are linked to ribosomopathies and possibly certain cancers. For example abnormal expression levels might have connections to Diamond-Blackfan anemia a disorder arising from defects in ribosomal function. In this context RPP25 may interact with proteins like RPL5 which is also associated with ribosomal biogenesis and linked diseases pointing to a potential pathway for therapeutic exploration.