Abcam, ab126489, Anti-StARD13 antibody

Size: 100µL
Rabbit Polyclonal StARD13 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STARD13.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human STARD13. The exact immunogen used to generate this antibody is proprietary information.Q9Y3M8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
StARD13 also known as DLC2 is a member of the START domain-containing proteins characterized by its RhoGAP activity which regulates Rho family GTPases by accelerating the hydrolysis of GTP to GDP. It has a molecular mass of approximately 112 kDa. This protein exhibits expression in various tissues including the liver where it significantly plays a role in cellular processes. StARD13 features a START domain responsible for lipid-binding anchoring it in cellular membranes and providing substrate specificity.
Biological function summary
StARD13 influences cellular organization by impacting actin cytoskeleton dynamics and cell migration. It interacts predominantly within protein complexes involving Rho GTPases such as RhoA and RhoC. The protein shapes cell shape and motility by acting as a tumor suppressor mainly through modulating actin cytoskeleton rearrangement. Additionally StARD13 maintains cellular homeostasis and suppresses cell proliferation in a normal tissue environment.
Pathways
StARD13 holds a notable place within signaling pathways like the Rho signaling pathway and the Hippo pathway. These pathways are essential for regulating cell proliferation motility and survival critical for maintaining cellular physiology and architecture. The StARD13 protein acts alongside other pathway-related proteins such as YAP in the Hippo pathway and the ROCK kinase in the Rho signaling pathway influencing various intracellular signaling cascades.
StARD13 shows notable associations with cancer and fibrosis. Research indicates its tumor suppressor role especially in the context of hepatocellular carcinoma where downregulation correlates with increased tumor progression and invasiveness. The relation with fibrosis particularly liver fibrosis highlights its involvement in tissue remodeling and wound healing processes. Additionally through disease mechanisms StARD13 connects to the p53 protein in cancer pathways enhancing apoptosis and suppressing abnormal cellular growth.