Abcam, ab126576, Anti-ETFDH antibody [3H2BG1]

Size: 100µg
Mouse Monoclonal ETFDH antibody. Suitable for WB, IHC-P and reacts with Rat, Cow, Mouse, Human samples. Cited in 4 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:3H2BG1,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Mouse, Rat, Cow, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
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Properties and Storage Information:
Form-Liquid, Purification technique-Precipitation Ammonium Sulphate, Purification notes-Produced in vitro using hybridomas grown in serum-free medium, and then concentrated by ammonium sulfate precipitation. Near homogeneity as judged by SDS-PAGE., Storage buffer-pH: 7.5Preservative: 0.02% Sodium azideConstituents: 99% HEPES buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ETFDH also known as Electron Transfer Flavoprotein Dehydrogenase plays an important role in transferring electrons within the mitochondrial respiratory chain. With a molecular mass of approximately 65 kDa it is predominantly expressed in tissues with high energy demands such as muscle and liver. ETFDH operates as a component of the electron transport chain facilitating electron transfer from the electron transfer flavoprotein (ETF) to the ubiquinone pool.
Biological function summary
The action of ETFDH assists in fatty acid and amino acid metabolism. As part of the larger electron transport chain complex ETFDH partners with both ETF-alpha and ETF-beta subunits to facilitate electron transfer. This process is key in the oxidation of fatty acids particularly in the beta-oxidation pathway. The functional activity of ETFDH helps convert energy stored in macronutrients into adenosine triphosphate (ATP) a necessary energy currency in cells.
Pathways
ETFDH has a critical role in both the beta-oxidation of fatty acids and the catabolism of certain amino acids. Within these pathways it acts as an intersection between the mitochondria and cellular energy production. ETFDH operates with other proteins such as ACAD9 and ACADVL to ensure efficient energy conversion and maintain cellular homeostasis. These pathways highlight ETFDH's involvement in mitochondrial function and overall energy metabolism.
Mutations in the ETFDH gene are linked to conditions like multiple acyl-CoA dehydrogenase deficiency (MADD) and glutaric acidemia type II. These metabolic disorders arise from deficiencies in energy metabolism often leading to severe clinical symptoms. ETFDH's interaction with proteins like ACAD9 can influence the severity and onset of these conditions emphasizing its medical significance in metabolic health. Understanding ETFDH's operation provides insight into potential therapeutic targets for related metabolic diseases.