Abcam, ab126694, Recombinant Human Cyt 19 protein

Size: 100µg
Recombinant Human Cyt 19 protein is a Human Full Length protein, in the 1 to 375 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9HBK9,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cyt 19 also known as CYP19 or aromatase is an important enzyme involved in steroid biosynthesis. It weighs about 58 kDa and is expressed in various tissues including adipose tissue gonads and the brain. The enzyme facilitates the conversion of androgens to estrogens by adding an aromatic ring a reaction necessary for maintaining hormone balance. This enzyme is integral to processes involving sex steroid formation and regulation.
Biological function summary
Cyt 19 plays a role in sexual development and reproductive function. It is a part of the cytochrome P450 enzyme family which is a group of heme-thiolate monooxygenases. As part of the family Cyt 19 contributes to the synthesis of estrogens from testosterone and has implications for fertility and gonadal function. Estrogens synthesized by Cyt 19 influence secondary sexual traits and regulate reproductive systems across various species.
Pathways
Cyt 19 influences the steroid biosynthesis and estrogen signaling pathways. It works closely with proteins like steroidogenic acute regulatory protein (StAR) and cytochrome P450 reductase which assist in electron transport necessary for its enzymatic activity. These pathways ensure the availability of estrogens important for modulating various physiological processes including reproductive organ function and bone density regulation.
Cyt 19 shows significant relevance in the context of breast cancer and polycystic ovary syndrome (PCOS). Anomalous expression or activity of Cyt 19 influences estrogen levels which can drive the proliferation of estrogen-receptor-positive breast cancer. Additionally altered activity can contribute to the hormonal imbalances found in PCOS. Researchers have studied the interaction between Cyt 19 and breast cancer susceptibility proteins like BRCA1 seeking to understand their contributions to cancer's development and progression.