Abcam, ab126941, Anti-ARPC1B antibody

Size: 50µL
Rabbit Polyclonal ARPC1B antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ARPC1B aa 50-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ARPC1B aa 50-250. The exact immunogen used to generate this antibody is proprietary information.O15143

Product details:
Keep as concentrated solution.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARPC1B also known as Actin-related protein 2/3 complex subunit 1B weighs around 41 kDa. This protein forms a part of the Arp2/3 complex which is instrumental in actin filament branching and growth. Researchers have detected ARPC1B expression in various tissues including blood cells and the skin highlighting its diverse functional roles in different cell types.
Biological function summary
ARPC1B contributes significantly to cell movement and shape maintenance. The protein acts as a component of the Arp2/3 complex which always requires additional nucleation factors to perform its function. This complex drives the reorganization of the actin cytoskeleton influencing cellular processes like migration and phagocytosis. It modulates the interaction of actin with branching networks thereby ensuring dynamic cellular adaptability to different environments.
Pathways
ARPC1B plays a critical role in the regulation of actin cytoskeleton and focal adhesion pathways. Scientists have associated ARPC1B with the WASP and WAVE proteins which stimulate actin assembly. These interactions enable ARPC1B to facilitate precise signaling pathways important for cell migration and immune responses. The protein’s participation in these pathways illustrates its key function in maintaining cytoskeletal integrity and cellular communication.
ARPC1B has connections to severe combined immunodeficiency and Wiskott-Aldrich syndrome. These conditions often manifest through mutations affecting the actin cytoskeleton. ARPC1B’s relationship with the WASP protein highlights its involvement in regulating immune cell function and signaling. For individuals with deficiencies in ARPC1B these immune complications underline the importance of understanding its function in therapeutic contexts.