Abcam, ab127165, Anti-Transportin-2 antibody

Size: 50µL
Rabbit Polyclonal Transportin-2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TNPO2 aa 550-850.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TNPO2 aa 550-850. The exact immunogen used to generate this antibody is proprietary information.O14787

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Transportin-2 also known as TNPO2 facilitates the import of proteins into the nucleus by recognizing nuclear localization signals. This protein plays an important role in nuclear-cytoplasmic transport. Transportin-2 weighs approximately 97 kDa and is mainly expressed in various tissues including the brain and testis. The protein functions as part of the karyopherin family which are important for nucleocytoplasmic transport.
Biological function summary
Transportin-2 mediates the translocation of certain RNA-binding proteins and unspliced viral RNA between the cytoplasm and the nucleus. The protein often associates with the importin-β family forming a complex for efficient cargo delivery to the nucleus. Its specificity and binding affinity for different proteins highlight its importance in cellular function especially in regulating protein traffic necessary for gene expression and viral replication processes.
Pathways
Transportin-2 participates in cellular transport and protein sorting pathways. It functions closely with proteins like RanGTP which regulates the directionality of nuclear import. Additionally Transportin-2 is a part of the nuclear import pathway where it maintains the nuclear-cytoplasmic balance of several other nuclear transport proteins.
Transportin-2 links to several neurological disorders and some types of cancer. Alterations in its function and expression levels can affect protein import contributing to conditions like Huntington's disease due to disrupted nuclear transport processes. It also associates with proteins like Importin-α in mediating abnormal protein expression that might lead to cancerous growths. Understanding Transportin-2’s role in these diseases could offer insights for developing therapeutic advancements.