Abcam, ab127559, Anti-WDR16 antibody

Size: 50µL
Rabbit Polyclonal WDR16 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CFAP52 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CFAP52 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q8N1V2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WDR16 also known as WD repeat domain 16 is a protein that is involved in several cellular processes through its structural role. It has a molecular mass of approximately 47 kDa and displays expression in various human tissues including the lungs brain and kidney. The protein belongs to the WD repeat protein family characterized by distinct WD repeat structures that facilitate protein-protein interactions.
Biological function summary
WDR16 contributes to important cellular functions and it often participates as part of multiprotein complexes. The protein shows involvement in the regulation of ciliary functions aiding in the proper formation and maintenance of cilia. This role makes it significant in supporting cells' roles in movement fluid flow and sensory functions. Through this biological involvement WDR16 helps ensure proper communication and signaling within cells that contain cilia.
Pathways
WDR16 plays a part in ciliary assembly and maintenance critical for the ciliogenesis pathway. This pathway involves several other proteins such as IFT20 which helps in the transport of ciliary components. Additionally WDR16 has interactions in the Wnt signaling pathway although its specific mechanisms are less thoroughly explored compared to its role in ciliary processes. These pathways emphasize WDR16's role in maintaining cellular structure and signaling required for normal cell function.
Mutations or dysfunction of WDR16 link to ciliopathies a group of disorders caused by defects in cilia structure and function. One such disease is nephronophthisis a kidney disorder characterized by inflammation and fibrosis. In this context WDR16 can connect with proteins like NEK8 which are implicated in similar pathways and disorders. Understanding these connections helps provide insight into the roles of WDR16 in disease pathology and potential therapeutic targets.