Abcam, ab127714, Anti-OTUD6B antibody

Size: 50µL
Rabbit Polyclonal OTUD6B antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human OTUD6B aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human OTUD6B aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8N6M0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OTUD6B also known as OTU domain-containing protein 6B functions as a deubiquitinating enzyme. It specifically targets ubiquitin chains on substrate proteins for removal which regulates protein stability and activity. The molecular mass of OTUD6B is approximately 37 kDa. Researchers found its expression in a variety of tissues with higher levels in lung and placenta tissues. This suggests its importance in those areas but it also appears present in several other tissues throughout the body.
Biological function summary
OTUD6B plays a significant role in cellular homeostasis by modulating protein turnover. Its enzymatic activity affects key regulatory proteins influencing cell cycle and signaling pathways. It does not seem to act within a larger protein complex but interacts individually with specific targets to exert its effects. Its deubiquitinating function impacts various cellular activities ensuring proper protein function and cell response.
Pathways
OTUD6B integrates into ubiquitin-proteasome pathways and impacts the regulation of protein degradation and turnover. It closely associates with cellular processes like cell cycle progression and apoptosis. OTUD6B interacts with proteins such as p53 and NF-kB playing a part in their stabilization and activity regulation. These interactions show its role in important signaling pathways that influence cell fate and stress response.
Alterations in OTUD6B function connect to cancer and neurodegenerative diseases. Dysregulation of its deubiquitinating activity can contribute to tumorigenesis through inappropriate protein stabilization affecting tumor suppressors or oncogenes. In neurodegenerative conditions abnormalities in protein degradation pathways can arise where OTUD6B's function becomes critical. It is connected with proteins like p53 and tau which are implicated in cancer progression and Alzheimer's disease respectively. Understanding OTUD6B's role could offer insight into new therapeutic approaches for these disorders.