Abcam, ab128404, Anti-HHV6 antibody [C3108-103]

Size: 50µg
Mouse Monoclonal HHV6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human betaherpesvirus 6 samples. Cited in 5 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:C3108-103,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human betaherpesvirus 6,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:Human herpes virus 6, B variant. Recognises a viron protein of 101 kD. Gives a cytoplasmic speckled pattern in IF.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle, Store undiluted

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HHV-6 also known as Human Herpesvirus 6 is a DNA virus with a double-stranded genome and an icosahedral capsid. The alternate name for this virus is Roseolovirus. It expresses in various human tissues especially in peripheral blood mononuclear cells and is a member of the Herpesviridae family. The virion size of HHV-6 is about 200 nm. HHV-6 antibodies like HHV-6 IgG are useful for diagnosing infections in the laboratory setting.
Biological function summary
HHV-6 targets immune cells particularly T lymphocytes and integrates its genome into the host’s DNA where it establishes a latent infection. This virus does not usually form part of a complex. However it can reactivate in conditions where the immune system is compromised such as in individuals undergoing immunosuppressive therapy. HHV-6 influences the function of the immune system and impacts the host's cellular environment through modulation of cytokine expression.
Pathways
The virus impacts immune modulation pathways particularly by affecting the IL-6 signaling pathway. Its interaction with the host's immune response influences not only cytokines but also relations with proteins like CD46 which HHV-6 uses as a cellular receptor for entry into human cells. By engaging these pathways HHV-6 plays a direct role in lymphocyte function and immune evasion.
HHV-6 is linked to conditions such as roseola infantum causing fever and rash in young children and has been associated with more severe conditions like encephalitis in immunocompromised individuals. The virus’s connection with diseases ties to its influence on proteins within the immune system including triggering alterations in cytokine profiles that may worsen the disease outcome.