Abcam, ab128943, Anti-RGS6 antibody [EPR6342]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RGS6 antibody. Suitable for WB and reacts with Mouse, Human, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6342,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Regulators of G-protein Signaling 6 (RGS6) is a multifunctional protein involved in the negative regulation of G-protein-coupled receptor signaling pathways. Commonly known as RGS6 this protein exhibits a mass of approximately 52 kDa. It is widely expressed in many tissues including the brain heart and liver. RGS6 contains a common RGS domain that accelerates the GTPase activity of G-alpha subunits facilitating the return of these subunits to their inactive GDP-bound form.
Biological function summary
RGS6 contributes to the fine-tuning of cellular signaling processes. It plays a significant role in nervous system function by modulating neurotransmitter release and signal transduction. RGS6 is part of a signaling complex that includes G-protein beta and gamma subunits which further refines its regulatory activity. This complex interaction helps to ensure precise control over timing and intensity of signal propagation in cells.
Pathways
RGS6 is an important component of the G-protein signaling pathway interacting with G-alpha subunits. It also has involvement in the MAPK/ERK signaling pathway where it influences cellular responses such as proliferation and differentiation. Related proteins in these pathways include other RGS family members and various MAP kinases that collaborate to maintain cellular homeostasis and response to environmental stimuli.
RGS6 has implications in conditions such as depression and cancer. It modulates pathways linked to these disorders for instance mood regulation and tumor proliferation. Through these functions RGS6 interacts with proteins like G-protein-coupled receptors and specific transcription factors associated with these diseases offering potential therapeutic targets for treatment.