Abcam, ab129166, Anti-NCS1 antibody [EPR7699]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NCS1 antibody. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human, Rat, Mouse samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7699,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target 'NCS1' also known as Neuronal Calcium Sensor 1 is a small protein with a mass of approximately 22 kDa. This protein binds calcium ions and plays an important role in calcium signaling pathways. It is broadly expressed in neuronal tissues where it assists in regulating neurotransmitter release and synaptic plasticity. NCS1 belongs to a family of calcium-binding proteins characterized by EF-hand motifs which allow calcium ion attachment and subsequent conformational changes.
Biological function summary
NCS1 modulates intracellular calcium concentrations which are critical for numerous cellular functions. It interacts with various signaling proteins and receptors impacting cell signaling and communication. NCS1 does not operate alone but functions as part of larger protein complexes which modulate its activity and extend its biological roles. Its involvement supports neuronal processes like growth and differentiation by modulating the effect of calcium signals within the nerve cells.
Pathways
NCS1 plays a role in the phosphoinositide signaling pathway and the regulation of calcium homeostasis. It works alongside proteins such as phosphatidylinositol 4-kinase III beta (PI4KB) to maintain the balance of calcium in cells. NCS1 participation in signaling pathways ensures that calcium influx and release from intracellular stores happen efficiently which is essential for the transmission of signals across synapses.
NCS1 is associated with neurological conditions such as schizophrenia and bipolar disorder. Alterations in NCS1 expression or function can affect calcium signaling leading to disruptions in neuronal communication and function. Furthermore NCS1 interacts with dopamine receptor D2 (DRD2) which is significant in the development of these psychiatric conditions. Understanding the role of NCS1 in these disorders can provide insights into potential therapeutic targets for managing such diseases.