Abcam, ab129176, Anti-MAT1A + MAT2A antibody [EPR7938]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal MAT1A antibody. Suitable for IP, WB and reacts with Human, Mouse, Rat, Recombinant full length protein - Human samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7938,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MAT1A also known as Methionine Adenosyltransferase 1A is an enzyme with a molecular mass of approximately 41 kDa. This enzyme is integral in the catalysis of the formation of S-adenosylmethionine (SAM) from methionine and ATP a fundamental reaction in cellular metabolism. MAT1A is expressed predominantly in the liver reflecting its significant role in hepatic function.
Biological function summary
This enzyme participates in critical cellular processes involving methylation. It is part of the methionine adenosyltransferase complex which is essential for supplying S-adenosylmethionine to multiple methylating reactions in the cell. These reactions include DNA methylation an important process in gene expression regulation and histone methylation influencing chromatin structure.
Pathways
MAT1A plays a role in the methionine cycle and transsulfuration pathway. These pathways are important for amino acid metabolism and synthesis detoxification and antioxidant production. The enzyme collaborates with MAT2A another isoenzyme which plays a role outside the liver in SAM synthesis thereby coordinating methylation processes across tissues.
Mutations or dysregulation of MAT1A can relate to liver diseases such as cirrhosis and liver cancer. These conditions can arise due to impaired SAM production that affects methylation and consequently gene expression and cellular maintenance. MAT1A interactions with MAT2A are important as imbalances in SAM levels can influence cancer progression in hepatic and non-hepatic tissues.