Abcam, ab129196, Anti-p39 antibody [EPR5075(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal p39 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR5075(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb
patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Protein p39 also known as cyclin Y is a protein with a mass of approximately 39 kDa. It plays a role in cell cycle regulation. Expression of p39 occurs mainly in neural tissues where it participates in control of neuronal development and synaptic function. In addition p39 associates with cell membranes indicating its potential involvement in signal transduction pathways.
Biological function summary
P39 functions as a regulatory partner in cyclin-dependent kinase (CDK) complexes. These complexes are essential during various phases of the cell cycle including G1/S transition and mitosis. By forming complexes with CDK5 p39 modulates neuronal processes and affects aspects such as neuronal migration and axonal guidance. Moreover p39 interacts with other signaling molecules potentially influencing synaptic plasticity.
Pathways
Research shows p39's integration within the cell cycle and neuronal signaling pathways. In cell cycle regulation it interacts with proteins like CDK5 to influence cellular proliferation and differentiation. Additionally p39 plays a role in the Wnt signaling pathway where it could affect cellular growth and differentiation through interactions with key proteins like GSK-3β.
P39 associates with neurodegenerative conditions including Alzheimer’s disease. Abnormal p39 expression levels may disrupt normal neuronal function and homeostasis leading to disease progression. The protein's connection to CDK5 which is implicated in Alzheimer’s highlights the significance of p39 as a potential therapeutic target. Furthermore irregularities in Wnt signaling linked to p39 may contribute to the development of other neurological disorders suggesting important roles for p39 in maintaining neural integrity.