Abcam, ab129485, Anti-THOC2/Tho2 antibody

Size: 100µg
Rabbit Polyclonal THOC2/Tho2 antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human THOC2 aa 1500 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human THOC2 aa 1500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8NI27

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
THOC2 also known as Tho2 is part of the THO complex and is an important player in mRNA processing and transport. This protein has an estimated mass of around 200 kDa and is mainly expressed in the nucleus of eukaryotic cells. THOC2 plays a significant role in RNA metabolism binding to nascent mRNA and helping with the integration of several other factors needed for RNA stability and transport to the cytoplasm.
Biological function summary
THOC2 is necessary for efficient mRNA export and is part of the larger transcription export (TREX) complex which involves several proteins including THOC1 THOC5 and UAP56. This complex couples transcription with mRNA processing contributing to the maturation and export of mRNA transcripts. THOC2 ensures the proper processing and exportation of mRNA preventing the accumulation of ribonucleoprotein complexes in the nucleus.
Pathways
THOC2 integrates into the process of gene expression where it links transcription with mRNA export. It participates in pathways related to RNA binding and export. During this THOC2 interacts with proteins such as ALYREF and SR proteins which further support the processes by facilitating efficient mRNA transport and splicing. Additionally the presence of THOC2 in the THO complex is essential for the stability of the complex influencing the overall gene expression regulation.
THOC2 mutations have associations with intellectual disabilities and other neurological issues. Mutations in the THOC2 gene can disrupt its normal function in RNA processing leading to deficits in brain development and function. Furthermore THOC2's connection with other THO complex proteins involves interactions implicated in these disorders. For example disruptions that affect the stability or function of other TREX components like UAP56 can amplify disease phenotypes by disturbing mRNA transport and processing.