Abcam, ab129767, Anti-CYTL1 antibody

Size: 100µg
Rabbit Polyclonal CYTL1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human CYTL1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CYTL1. The exact immunogen used to generate this antibody is proprietary information.Q9NRR1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab129767 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen., Storage buffer-pH: 7Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CYTL1 also known as cytokine-like protein 1 or C17orf99 is a protein that plays a role in various cellular processes. It has an approximate molecular mass of 19 kDa. Scientists have observed its expression in a wide range of tissues but it is particularly prominent in cartilage tissue and the immune system suggesting its involvement in functions related to these areas. CYTL1 does not appear to have a highly specific pattern of distribution as it is also found in the respiratory and cardiovascular systems making its mechanical functions intriguing for further research.
Biological function summary
CYTL1 acts as a regulator in processes like cell adhesion migration and immune responses. While it isn't part of a larger complex it interacts closely with other cellular components to modulate these activities. Within immune responses CYTL1 contributes by modulating cytokine signaling potentially influencing the behavior of immune cells in response to inflammatory signals. This regulation is essential in maintaining a balanced immune environment and preventing excessive inflammation.
Pathways
CYTL1's biological function connects to the NF-kB and JAK-STAT signaling pathways. In the NF-kB pathway CYTL1 indirectly influences the expression of genes involved in inflammation and apoptosis. While in the JAK-STAT pathway CYTL1 modulation aids in mediating the effects of cytokines and promotes immune cell proliferation and differentiation. Related proteins like IL-6 and TNF-alpha often interact within these pathways and CYTL1 acts as a modulating entity that helps fine-tune the cellular responses.
Researchers have linked CYTL1 to potential roles in osteoarthritis and rheumatoid arthritis. In these conditions its expression level might affect cartilage integrity and inflammatory response. CYTL1 may interact with other proteins like MMPs (matrix metalloproteinases) in arthritis facilitating changes in cartilage matrix components. Understanding the precise role of CYTL1 in these diseases could offer new insights into therapeutic targets for mitigating joint degradation and inflammation.