Abcam, ab129895, Anti-OR10AD1 antibody

Size: 100µg
Rabbit Polyclonal OR10AD1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human OR10AD1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human OR10AD1. The exact immunogen used to generate this antibody is proprietary information.Q8NGE0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OR10AD1 also known as Olfactory Receptor 10AD1 is a G-protein coupled receptor involved in olfactory signal transduction. It has a molecular mass of approximately 34 kDa. This olfactory receptor is expressed in the sensory neurons of the olfactory epithelium. OR10AD1 contributes to detecting specific odorant molecules helping to initiate smell perception.
Biological function summary
The olfactory receptor 10AD1 contributes to the detection of chemical stimuli necessary for olfactory perception. It forms part of a vast family of olfactory receptors which work collectively to identify a wide range of odorant molecules. It has a role in a sophisticated system that helps animals recognize food predators and mating partners based on scent.
Pathways
The olfactory transduction pathway involves OR10AD1 translating external chemical signals into neuronal responses. This receptor associates with the G-protein olfactory transduction cascade where it activates adenylate cyclase leading to the production of cAMP. It might relate to other olfactory receptors such as those activating similar signaling molecules like AC3 facilitating the detection of diverse odorants.
Researchers have not extensively linked OR10AD1 to specific pathologies. However olfactory receptors in general have potential implications in conditions like anosmia or the loss of smell which can affect the quality of life. Some studies explore their roles in neurological diseases due to their expression in brain regions beyond the olfactory epithelium where OR10AD1 could interact with other proteins like OMP (Olfactory Marker Protein).