Abcam, ab130403, Anti-Spir-1 antibody

Size: 100µL
Rabbit Polyclonal Spir-1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SPIRE1 aa 350-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SPIRE1 aa 350-500. The exact immunogen used to generate this antibody is proprietary information.Q08AE8

Product details:
Store product undiluted. For continuous use, store at 2-8°C for one-two days. Working dilution samples should be discarded if not used within 12 hours. The antibody solution should be gently mixed before use.
This antibody is mono-specific.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Spir-1 also known as SPIR1 is a protein that functions as an actin nucleator. Its molecular mass is approximately 82 kDa. Spir-1 polymerizes actin by initiating the formation of new actin filaments. It has a role in controlling cytoskeletal dynamics important for cellular structure and movement. Spir-1 is expressed in a variety of human tissues including the brain where it shows particular activity in embryonic and neural tissues. These actin-modulating properties contribute to its regulation of cellular processes fundamental for organismal development.
Biological function summary
Spir-1 influences the organization of the actin cytoskeleton acting as an important factor in cellular motility and shape determination. It forms a complex with other actin-related proteins such as the formin protein family. This complex enables Spir-1 to work efficiently in actin polymerization ensuring the proper assembly of actin filaments. Spir-1's role becomes critical during processes like cell division and intracellular transport where actin dynamics are essential.
Pathways
Spir-1 participates in the regulation of the actin cytoskeleton pathway integral for maintaining cellular architecture and facilitating intracellular transport. Spir-1 closely interacts with proteins like formin homology proteins to control actin dynamics within this pathway. Another important pathway where Spir-1 is active is the signal transduction pathway which involves communication within cells to coordinate responses to external signals influencing how cells change their behavior or state in reaction to environmental cues.
Spir-1 has associations with neurodevelopmental disorders and cancer. Disruptions in actin dynamics influenced by aberrant Spir-1 function may lead to impaired neural development linking it to developmental brain disorders. Additionally anomalous Spir-1 activity could contribute to cancer progression as changes in cytoskeleton organization can affect cell proliferation and movement elements important for tumor growth and metastasis. Proteins such as cortactin another actin-associated protein also tie into these disease processes highlighting the complex network of actin regulatory proteins in disease states.