Abcam, ab132727, Recombinant Human PDGFC protein

Size: 10µg
Recombinant Human PDGFC protein is a Human Full Length protein, in the 1 to 345 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:SDS-PAGE, ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9NRA1,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein PDGFC also called Platelet-Derived Growth Factor C functions mechanically as a growth factor involved in cell proliferation migration and survival. It belongs to the PDGF family and exhibits a molecular mass of approximately 38 kDa. PDGFC expresses in a variety of tissues such as the heart kidney and skeletal muscle. Unlike other PDGF family members PDGFC has a unique hinge region that requires proteolytic activation to reveal its growth factor activity.
Biological function summary
PDGFC supports angiogenesis and tissue remodeling which are essential for normal developmental processes and wound healing. It often forms part of a PDGF receptor-ligand complex by binding to the alpha and beta PDGF receptors. Upon binding PDGFC activates signaling pathways that result in cellular responses significant in tissues undergoing repair or in presence of injury.
Pathways
PDGFC plays a part in the MAPK and PI3K/AKT signaling pathways which regulate several cellular mechanisms. As it interacts with PDGF receptors PDGFC can collaborate with other proteins such as PDGFA and PDGFB both of which are significant for initiating similar pathways. These connections allow PDGFC to influence processes like cell cycle progression and apoptosis key elements in maintaining cellular homeostasis.
Alterations in PDGFC expression or signaling link to certain conditions such as cancer and fibrotic diseases. Overexpression of PDGFC relates to tumor growth and metastasis partially due to its role in angiogenesis where it can interact with proteins like VEGF. In fibrosis PDGFC acts by promoting excessive extracellular matrix production further involving it with proteins like transforming growth factor-beta (TGF-β) which contribute to tissue scarring and organ dysfunction.