Abcam, ab132761, Recombinant Human MG53 protein

Size: 10µg
Recombinant Human MG53 protein is a Human Full Length protein, in the 1 to 268 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:Tag free,
Applications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q6ZMU5,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Product details:
This product was previously labelled as TRIM72.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MG53 also known as TRIM72 is a protein that plays an important role in membrane repair. This protein has a molecular mass of approximately 72 kDa and is classified as a member of the tripartite motif-containing (TRIM) protein family. MG53 is expressed highly in striated muscles including the cardiac and skeletal muscles. Its mechanical action involves sensing membrane disruptions and facilitating the repair process by recruiting vesicles to the site of injury.
Biological function summary
MG53 acts as a critical factor in maintaining cellular membrane integrity. It forms part of a complex network where it interacts with other proteins to orchestrate the membrane repair process. MG53 functions as a scaffold bringing together various repair components and coordinating their activity to mend damaged membranes. This repair process is essential for muscle cells which frequently experience mechanical stress.
Pathways
MG53 integrates into cellular repair pathways and is pivotal in the response to membrane damage. It interacts with important pathways like the IRS1/PI3K/AKT signaling pathway where it modulates cellular responses to stress and injury. MG53 also associates with other proteins such as caveolin-3 assisting in stabilizing the membrane during injury response.
MG53 has relevance to conditions like muscular dystrophy and cardiomyopathy. Mutations or dysregulation of MG53 can lead to inadequate membrane repair contributing to muscle weakness and cardiac dysfunction. In muscular disorders MG53 interacts with dysferlin another repair protein to support membrane stabilization and disruptions in this interaction exacerbate disease progression.