Abcam, ab133591, Anti-SUN2 antibody [EPR6556]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SUN2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6556,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SUN2 also known as Sad1 and UNC84 domain containing 2 is a protein that plays a fundamental role in the positioning of the nucleus in cells. It has a mass of approximately 89 kDa. This protein localizes to the inner nuclear membrane where it is involved in tethering the nucleus to the cytoskeleton. SUN2 is mainly expressed in tissues exhibiting high mechanical stress such as muscle and bone tissue. Its structural role anchors the nuclear lamina to the cytoskeleton helping to maintain cellular integrity.
Biological function summary
SUN2 connects the nuclear interior with the cytoskeleton through the LINC complex (Linker of Nucleoskeleton and Cytoskeleton). This complex also includes other proteins like Nesprin and Lamins helping to transmit mechanical signals across the nuclear envelope. SUN2 plays an essential role in processes like cell division nuclear migration and chromosomal positioning. Its function in the LINC complex makes it a significant player in maintaining nuclear morphology and ensuring proper cell division.
Pathways
SUN2 is involved in the mechanotransduction and cell-cycle regulation pathways. In mechanotransduction SUN2 helps translate mechanical signals into biochemical ones therefore influencing gene expression. Related proteins like Nesprin-2 interact within the LINC complex and contribute to these pathways. In cell-cycle regulation the protein helps align the mitotic spindle through connection with components of the cytoskeleton supporting accurate cell division. These pathways demonstrate SUN2's contribution to cellular responses to mechanical stimuli and cell growth regulation.
Studies indicate that SUN2 mutations or abnormal expression levels are associated with muscular dystrophy and cancer. In muscular dystrophy defects in SUN2 can lead to impaired nuclear anchoring contributing to muscle weakness. It interacts with Lamin A/C and defects in these proteins are also linked to muscular dystrophies. In cancer SUN2 dysregulation may affect cellular architecture and chromosomal stability contributing to tumorigenesis. Understanding SUN2's roles and interactions offers potential pathways for therapeutic interventions.