Abcam, ab133753, Anti-KCHIP1 antibody [EPR7624]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal KCHIP1 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7624,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KCHIP1 also known as Potassium Channel Interacting Protein 1 or KCNIP1 is a protein of approximately 28 kDa. It is expressed mainly in the brain with significant presence in neurons. Mechanically KCHIP1 interacts with and modulates the activity of Kv4 potassium channels. These are responsible for transient A-type potassium currents which play a role in stabilizing the neuronal resting membrane potential and shaping action potentials.
Biological function summary
In neuronal environments KCHIP1 acts as a subunit of the Kv4 channel complex. Its binding influences the kinetic properties and surface expression of Kv4 channels affecting potassium ion conductance. By adjusting the availability and activity of these channels KCHIP1 regulates neuronal excitability and plasticity. This control is important in maintaining appropriate signaling within neural circuits and any dysfunction in this component may affect neuronal communication.
Pathways
Potassium channel modulation by KCHIP1 occurs in the regulation of membrane excitability and electrical signaling in neurons. This function intersects with the MAPK signaling pathway a critical pathway responsible for various cellular responses including growth and stress responses. KCHIP1's role within these pathways links it to proteins such as Kv4.2 and Kv4.3 emphasizing its function in regulating neuronal activity and responses.
KCHIP1 has associations with neurodegenerative diseases like Alzheimer's. Impaired function or expression of KCHIP1 can lead to dysregulation of potassium channel activity impacting neuronal cell signaling and health. Furthermore its potential link with the Alzheimer's-related protein tau indicates that KCHIP1 might be involved in processes underlying tauopathy which affects neuronal stability and function. Understanding these interactions provides insights into therapeutic targets for managing neurodegenerative conditions.