Abcam, ab133757, Anti-NPY5R antibody [EPR8382]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NPY5R antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 8 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8382,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NPY5R also known as the Neuropeptide Y receptor Y5 plays an important role in the human body. It is a G-protein-coupled receptor with a molecular weight around 50 kDa. NPY5R is mainly expressed in the central nervous system especially in the hypothalamus. This receptor is one of several receptors that bind to the neuropeptide Y (NPY) peptide YY (PYY) and pancreatic polypeptide (PP) which are involved in various physiological processes.
Biological function summary
NPY5R influences several important functions related to energy balance and feeding behavior. It is part of the NPY receptor family and works by activating intracellular signaling pathways that affect appetite regulation and energy homeostasis. The receptor's activity can modulate food intake making it an important player in energy metabolism. It does not form part of a protein complex but interacts directly with ligands such as NPY and PYY.
Pathways
NPY5R participates in the neuropeptide signaling pathway and the G-protein-coupled receptor pathway. These pathways significantly impact the regulation of hunger and satiety signals. NPY5R closely interacts with other neuropeptide Y receptors such as NPY1R and NPY2R which together create a network that regulates feeding behavior and body weight. These interactions amplify the receptor's role in the central control of energy balance.
NPY5R has a connection to obesity and metabolic syndromes due to its involvement in appetite and energy regulation. Its dysregulation is linked to increased food intake and weight gain. Additionally the receptor has associations with conditions such as anxiety where altered NPY signaling may impact stress responses. NPY and its receptors including NPY5R also relate to other receptors like NPY2R in the modulation of emotional states and metabolic diseases making it a potential target for therapeutic interventions in these conditions.