Abcam, ab134137, Anti-cadherin 10 antibody [EPR5115]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal cadherin 10 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR5115,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cadherin-10 often referred to as CDH10 is a member of the classical cadherin family which are vital components of calcium-dependent cell-cell adhesion. This protein is approximately 98 kDa in mass. CDH10 is expressed widely in the central nervous system and is also present in other tissues such as the pancreas and kidney. The cadherin family plays a significant role in mediating homophilic interactions between cells influencing tissue architecture and integrity.
Biological function summary
Cadherin-10 assists in maintaining precise cellular recognition and adhesion. It is particularly involved in the development and maintenance of neural circuits suggesting its involvement in the complexity of brain network formation. Cadherin-10 operates as part of adhesion complexes interacting with cytoplasmic components that link to the actin cytoskeleton thereby influencing cell signaling pathways and cellular communication.
Pathways
Cadherin-10 contributes significantly to the Wnt signaling pathway and adherens junction pathways. These pathways are critical for processes such as cellular differentiation migration and organization. Cadherin-10 has related interactions with proteins like beta-catenin within these pathways which facilitates signal transduction and cell structural integrity.
Alterations in cadherin-10 can affect neurological and developmental conditions. Mutations or dysregulation of CDH10 have associations with autism spectrum disorders impacting neural communication genes. Similarly changes in cadherin-10 expressions also show connections to manic disorders implying a role in emotional regulation pathways linked to neuropsychiatric proteins such as N-cadherin and synaptic adhesion molecules.