Abcam, ab134145, Anti-Cdx4 antibody [EPR5760]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CDX4 antibody. Suitable for WB and reacts with Rat, Human, Mouse samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR5760,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cdx4 also known as Caudal type homeobox transcription factor 4 plays an important role in embryonic development and cell differentiation. This protein with an estimated mass of approximately 31 kDa acts as a transcription factor that bind DNA at specific sites regulating gene expression. Cdx4 is mostly expressed in tissues such as the developing testes and parts of the nervous system. The expression pattern hints at its importance during specific stages of early development.
Biological function summary
Cdx4 influences the regulation of genes involved in the posterior body patterning. This transcription factor does not work alone; it participates in complexes with other homeobox proteins to modulate target genes. During early development Cdx4 helps establish the positional identity of cells contributing significantly to vertebrate body formation. By controlling the expression of critical genes Cdx4 influences processes like cell proliferation and differentiation.
Pathways
Cdx4 integrates into the Wnt signaling pathway which is essential for cellular proliferation and differentiation. Cdx4 interacts with the canonical Wnt pathway tuning the transcriptional activity of downstream effectors. Another associated pathway is the retinoic acid signaling where Cdx4 may co-regulate gene expression. Proteins such as beta-catenin can collaborate with Cdx4 mediating its effects on transcriptional regulation within these pathways.
Cdx4 has implications in certain types of leukemia and congenital abnormalities. In leukemia abnormal regulation of Cdx4 might contribute to the uncontrolled proliferation of hematopoietic cells often involving other proteins such as Hox gene cluster members. In congenital developmental disorders altered function or mutation of Cdx4 may lead to improper body segmentation and formation potentially interacting with proteins like retinoic acid receptors to influence disease outcomes.