Abcam, ab134152, Anti-Somatostatin Receptor 2 antibody [UMB1] - C-terminal

Size: 20µL / 100µL / 1mL
Anti-Somatostatin Receptor 2 antibody [UMB1] - C-terminal (ab134152) is a rabbit monoclonal antibody detecting Somatostatin Receptor 2 in Western Blot, IHC-P . Suitable for Human, Mouse, Rat . - Clone UMB1 is the most cited clone to Somatostatin Receptor 2 - Biophysical QC for unrivalled batch-batch consistency - Over 120 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:UMB1,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:The specificity of this antibody was demonstrated in a Somatostatin Receptor 2-deficient mouse model. Refer to Fischer et al.

Product details:
Anti-Somatostatin Receptor 2 antibody [UMB1] - C-terminal (ab134152) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IHC-P and WB.
Anti-Somatostatin Receptor 2 antibody [UMB1] - C-terminal (ab134152) was first used in a scientific publication in 2008 and has been cited over 127 times in peer reviewed journals. It's performance in IHC in human samples is trusted by the scientific community.
Abcam's high quality manufacturing and validation processes ensure Anti-Somatostatin Receptor 2 antibody [UMB1] - C-terminal (ab134152) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
Anti-Somatostatin Receptor 2 antibody [UMB1] - C-terminal (ab134152) specifically detects Somatostatin Receptor 2 (UniProt ID: P30874; Molecular weight: 42kDa) and is sold in 100 µL and 1 mL selling sizes.
Conjugation-ready, carrier free format available for antibody clone UMB1 -
ab216649
Antibody clone UMB1 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor
647, Alexa Fluor
488, Alexa Fluor
594, Alexa Fluor
568, Alexa Fluor
555, Alexa Fluor
ab225183
ab311039
ab311816
ab313099
ab313292
ab321081
Somatostatin Receptor 2 (SSTR2) is overexpressed in various tumors and plays a role in inhibiting tumor growth by mediating antiproliferative signals. It is also a target for diagnostic imaging and therapeutic interventions, particularly in neuroendocrine tumors.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The somatostatin receptor 2 (SSTR2) also known as SS2R serves as a G protein-coupled receptor with a molecular mass of approximately 40-60 kDa. SSTR2 specifically binds somatostatin a peptide hormone that regulates the endocrine system neurotransmission and cell proliferation via interaction with various somatostatin receptors. Scientists find SSTR2 expressed in high levels in the pituitary gland central nervous system gastrointestinal tract and pancreatic cells.
Biological function summary
Somatostatin receptor 2 mediates the inhibitory effects of somatostatin on cell growth and the release of other hormones. It functions as part of the receptor complex modulating intracellular signaling pathways. SSTR2 often interacts closely with other molecules like G proteins to inhibit adenylyl cyclase reducing cyclic AMP (cAMP) levels and influencing diverse cellular responses. The receptor's ability to influence such processes emphasizes its role in maintaining cellular and systemic homeostasis.
Pathways
Somatostatin receptor 2 plays an important role in the inhibitory signaling pathways related to growth hormone regulation and neurotransmitter release. SSTR2 actively participates in the somatostatin signaling pathway intimately interacting with proteins such as adenylate cyclase and phospholipase C. Another important pathway includes the regulation of the MAPK pathway serving to modulate cell proliferation and survival reiterating its regulatory function within endocrine signaling and cellular communication.
Somatostatin receptor 2 demonstrates significant involvement in neuroendocrine tumors and acromegaly. The overexpression of SSTR2 in neuroendocrine tumors provides a valuable target for diagnostic imaging and therapeutic interventions using somatostatin analogs. In acromegaly where excess growth hormone production occurs SSTR2's modulation of growth hormone release becomes important; it often works alongside growth hormone receptors and IGF-1 to limit abnormal growth. Therefore the receptor's targeting offers therapeutic potential and advances disease understanding.