Abcam, ab134556, Anti-p46 antibody

Size: 100µg
Rabbit Polyclonal p46 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human POLDIP3 aa 350 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human POLDIP3 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9BY77

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab134556 is affinity purified using an epitope specific to p46 immobilized on a solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
P46 also known as heat shock protein 46 (HSP46) is a molecular chaperone within the heat shock protein family. It maintains a mass of approximately 46 kDa and is ubiquitously expressed in various tissues. The protein assists in protein folding and prevents the aggregation of misfolded proteins. It acts in cellular stress responses aiding cells in coping with conditions like heat or oxidative stress. Researchers recognize its important role in maintaining cellular protein homeostasis.
Biological function summary
Heat shock protein 46 is integral in cellular protection during stress conditions. It participates in forming complexes with other heat shock proteins enhancing its function in assisting proteins during synthesis and repair. This protein acts in maintaining the stability and function of other proteins preserving cellular health under stress. Its involvement in cellular processes signifies its importance in both cellular functioning and stress response mechanisms.
Pathways
P46 plays a critical role in the heat shock response and protein quality control pathways. It interacts with proteins such as HSP70 and HSP90 which participate in similar pathways ensuring proper folding and stability of newly synthesized proteins. These pathways protect cells from damage during stress connecting p46 to broader physiological responses. Its presence in these pathways emphasizes its significance in cellular recovery and adaptation processes.
P46 connects to neurodegenerative diseases and cancer. In neurodegenerative diseases such as Alzheimer's its function becomes important due to the accumulation of misfolded proteins sharing pathways with proteins like HSP70 which also counteracts protein misfolding. In cancer the overexpression of p46 has been observed linking it to tumor progression where it may stabilize proteins required for tumor growth and survival. These connections highlight how alterations in p46 levels may contribute to disease development and progression.