Abcam, ab134757, Anti-LARP7 antibody

Size: 100µg
Rabbit Polyclonal LARP7 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human LARP7 aa 500 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human LARP7 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q4G0J3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LARP7 also known as La-related protein 7 is a protein with a mass of approximately 63 kDa. It plays an important role in RNA polymerase II-dependent transcription by stabilizing the 7SK snRNP complex. LARP7 is widely expressed in various tissues including the brain liver and kidney. Its expression indicates its involvement in fundamental cellular processes.
Biological function summary
LARP7 stabilizes the 7SK snRNA which forms part of a multiprotein complex that regulates transcription elongation. This complex controls the activity of positive transcription elongation factor b (P-TEFb) a critical component in managing RNA polymerase II transcription. Through its interaction with the 7SK snRNP complex LARP7 helps regulate gene expression by controlling transcription elongation and maintaining proper cellular function.
Pathways
LARP7 plays a significant role in the regulation of gene expression and transcription elongation pathways. It directly interacts with P-TEFb impacting the control of transcriptional elongation factors. LARP7's function in these pathways highlights its relationship with transcription-related proteins highlighting its integrative role in managing cellular transcription processes.
Mutations or dysfunctions in LARP7 have associations with certain types of cancer and Alazami syndrome a rare developmental disorder. LARP7's regulatory interaction with P-TEFb and its involvement in transcription elongation implicate it in these conditions. Dysfunctional LARP7 activity can lead to misregulated gene expression contributing to disease pathogenesis and progression.