Abcam, ab134938, Anti-ERp18 antibody [EPR9024]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ERp18 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9024,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ERp18 also known as PDIA6 or Protein Disulfide Isomerase Family A Member 6 is an endoplasmic reticulum (ER) resident protein with a molecular mass of approximately 18 kDa. This protein is known to act as a chaperone and assists in protein folding by catalyzing disulfide bond formation. ERp18 is widely expressed in various tissues particularly in those with high protein synthesis demands such as the liver and pancreas. It localizes mainly within the lumen of the ER.
Biological function summary
ERp18 plays a role in maintaining protein homeostasis. As a member of the protein disulfide isomerase (PDI) family it is involved in the formation and rearrangement of disulfide bonds essential for proper protein architecture. ERp18 functions collaboratively with other PDIs in the ER suggesting it may be part of a larger protein complex. The efficient folding and structural stabilization of proteins are critical for cellular function and survival.
Pathways
ERp18 contributes significantly to the protein-folding pathway and is linked to the unfolded protein response (UPR). The protein is instrumental in mitigating ER stress conditions which arise when there is an accumulation of misfolded proteins. By interacting with other PDI family proteins like PDI itself and ERp72 ERp18 ensures proteins achieve correct configurations which is necessary for maintaining cellular equilibrium and preventing apoptosis.
The malfunction or dysregulation of ERp18 associates with certain neurodegenerative diseases such as Alzheimer's disease where protein misfolding plays an important role. Moreover it has connections to cancer where the proliferation of cells often correlates with increased protein synthesis and folding demands. ERp18 interacts with proteins involved in these diseases like amyloid precursor protein (APP) in Alzheimer's and HIF-1α in cancer highlighting its importance in disease contexts.