Abcam, ab135842, Anti-Semaphorin 3c antibody

Size: 100µg
Rabbit Polyclonal Semaphorin 3c antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human SEMA3C.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SEMA3C. The exact immunogen used to generate this antibody is proprietary information.Q99985

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab135842 was affinity-purified from rabbit antiserum by immunogenic peptide affinity-chromatography., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Semaphorin 3c also known as Sema3C is a secreted protein that plays a role in signal transduction. It has a mass of approximately 89 kDa. Researchers find that Sema3C is expressed in various tissues including the brain lungs and heart. This protein is part of the semaphorin family which is known for guiding axonal growth during neural development. Sema3C functions through binding to neuropilin-1 and -2 receptors facilitating essential processes in cell signaling.
Biological function summary
Semaphorin 3c has several effects on cellular dynamics. It influences axonal guidance angiogenesis and cell migration. Sema3C forms part of complex interactions with receptors and cytoplasmic proteins affecting the structure and function of the cytoskeleton in developing neurons. Additionally it plays a distinct role in vascular remodeling by regulating endothelial cells and smooth muscle proliferation. These functionalities highlight its involvement in tissue morphogenesis and development.
Pathways
Semaphorin 3c is an important player in neural development and vascular-related pathways. It interacts significantly in the axon guidance pathway where it provides directionality to growing neurons. In this context proteins such as plexins and neuropilins are directly associated with Sema3C facilitating its function in axon direction guidance. Additionally it is a part of the VEGF signaling pathway affecting angiogenic processes through interactions with VEGF family members and their respective receptors.
Semaphorin 3c is notably implicated in cancer progression and cardiovascular abnormalities. Aberrant expression of Sema3C associates with several cancer types where it can influence tumor growth and metastasis. In cardiovascular disorders anomalies in Sema3C levels are linked to conditions such as atherosclerosis. It interacts with proteins like vascular endothelial growth factor (VEGF) contributing to pathogenesis through altered cellular proliferation and migration in affected tissues.