Abcam, ab136407, Anti-Neurofibrillary tangles antibody

Size: 50µL
Rabbit Polyclonal Neurofilament heavy polypeptide antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:ab136407 specifically stains neurofibrillary tangles and degenerating plaque neurites in cases of Alzheimer's disease, Down's Syndrome and normal aged individuals.

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Preservative: 0.01% Thimerosal (merthiolate), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Neurofibrillary tangles also known as neuro tangles result from abnormal accumulations of the tau protein. Tau a microtubule-associated protein with a mass of about 60 kDa typically stabilizes microtubules in neuronal axons. Normally neurons express tau in the central nervous system (CNS) where it supports axonal transport by binding to and stabilizing microtubules. However misfolded tau proteins form aggregates leading to the development of neurofibrillary tangles.
Biological function summary
Tau proteins in neurons become hyperphosphorylated triggering their detachment from microtubules. This hyperphosphorylation causes tau proteins to misfold and aggregate into paired helical filaments and straight filaments. These aggregates are not part of a complex but compromise neuronal function by disrupting intracellular transport. The accumulation of such aggregates interferes with cell health and synaptic function contributing to neurodegeneration.
Pathways
Tau pathology involves several important cellular processes. The tau protein participates in signal transduction pathways such as the MAPK/ERK pathway and the microtubule assembly pathway. Misregulated tau phosphorylation impacts microtubule stability linking it to neuronal signaling alterations. Other proteins like glycogen synthase kinase 3-beta (GSK3β) and cyclin-dependent kinase 5 (CDK5) modulate tau hyperphosphorylation within these pathways affecting tau's normal function and leading to its aggregation.
Neurofibrillary tangles primarily relate to Alzheimer's disease and frontotemporal dementia. These tau aggregates are associated with neuronal death and cognitive decline. In Alzheimer's disease beta-amyloid accumulation can further influence tau pathology by promoting tau phosphorylation through pathways involving GSK3β. In frontotemporal dementia mutations in the MAPT gene encoding tau lead to neurofibrillary tangle formation contributing to the disease's progression. These tangles and accompanying neuronal loss characterize tauopathies underlining their significance in neurodegenerative disease research.