Abcam, ab137073, Anti-ALDH16A1 antibody [EPR9216]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal A16A1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9216,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ALDH16A1 or aldehyde dehydrogenase 16 family member A1 belongs to the aldehyde dehydrogenase superfamily. This protein does not have well-documented enzymatic activity but it shares structural similarity with other family proteins suggesting a potential role in aldehyde metabolism. ALDH16A1 has a molecular mass of approximately 83 kDa. The protein expresses mainly in liver kidney and other tissues though its exact function remains unclear.
Biological function summary
Members of the aldehyde dehydrogenase family act in detoxification processes by oxidizing aldehydes into carboxylic acids reducing cellular damage. While ALDH16A1's activity remains undetermined its expression profile implies involvement in pathways where aldehyde metabolism impacts critical cellular functions. It does not form a known complex but its similarity with other aldehyde dehydrogenases suggests a supporting role in cellular detoxification pathways.
Pathways
Amino acid metabolism and detoxification pathways potentially involve ALDH16A1 due to its homology with other aldehyde dehydrogenases. This protein potentially interacts with enzymes such as ALDH2 which participates in ethanol metabolism and detoxification. Both proteins play roles in mitigating oxidative stress and processing toxic aldehydes ensuring cellular homeostasis.
Polymorphisms or dysregulation in ALDH16A1 may correlate with metabolic disorders particularly those affecting kidney function. Further research implicates altered expression of this protein in conditions like diabetic nephropathy. The association with diabetes might tie into dysregulated aldehyde detoxification linking ALDH16A1 indirectly to proteins like ALDH2 known for roles in managing reactive aldehyde species and oxidative stress.