Abcam, ab137214, Anti-SLC5A6 antibody

Size: 100µg
Rabbit Polyclonal SLC5A6 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SLC5A6.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC5A6. The exact immunogen used to generate this antibody is proprietary information.Q9Y289

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLC5A6 also known as the sodium-dependent multivitamin transporter (SMVT) mechanically functions as a transmembrane protein responsible for the uptake of vital water-soluble vitamins and cofactors such as biotin pantothenic acid and lipoate. The protein has an approximate molecular mass of 72 kDa. It is expressed in various tissues with high levels observed in the intestines kidneys and placenta indicating its role in nutrient absorption and metabolic processes.
Biological function summary
SLC5A6 is essential for the efficient transport of vitamins across cell membranes using sodium gradient as the driving force. It transports vitamins into cells where they participate as coenzymes in several enzymatic reactions. This transporter does not form part of a larger protein complex but functions individually to link dietary intake with cellular nutrient requirements. The absorption through SLC5A6 impacts various biosynthetic processes as biotin and pantothenate contribute to fatty acid synthesis and energy metabolism.
Pathways
The role of SLC5A6 in nutrient absorption connects it to critical metabolic pathways such as the biotin and CoA biosynthetic pathways. Its function impacts cellular metabolism by providing essential cofactors for carboxylation reactions and energy production. SLC5A6 interacts with enzymes that rely on these vitamin-derived cofactors maintaining cellular metabolic equilibrium essential for cell growth and energy balance.
Mutations or dysfunction in SLC5A6 can lead to conditions like biotinidase deficiency which results in various neurological and dermatological symptoms. There are connections between SLC5A6 malfunctions and certain metabolic disorders due to impaired nutrient uptake linking this transporter to proteins involved in biotin metabolism. Research indicates possible associations of SLC5A6 with neurological disorders as biotin deficiency impacts brain functions and development.