Abcam, ab137247, Anti-SFRS7/SRSF7 antibody

Size: 100µg
Rabbit Polyclonal SFRS7/SRSF7 antibody. Suitable for IHC-P, IP and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SRSF7 aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SRSF7 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q16629

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab137247 was affinity purified using an epitope specific to SRSF7/SRSF7 immobilized on solid support, Storage buffer-pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SFRS7 also known as SRSF7 is a member of the serine/arginine-rich family of proteins that functions as an essential splicing factor. It has a mass of approximately 27 kDa. SRSF7 shows expression in various tissues with notable presence in the nucleoplasm of cells. Mechanically SRSF7 has binding affinity for RNA sequences facilitating alternative splicing by interacting with pre-mRNA. This protein plays a significant role in post-transcriptional regulation influencing the maturation and diversity of mRNA transcripts.
Biological function summary
SRSF7 contributes to the regulation of gene expression and is involved in spliceosome formation though it is not strictly part of the spliceosomal core complex. It influences exon skipping and inclusion which affects various functional mRNA variants. SRSF7 enables cellular responses to changes in internal and external environments by altering gene expression patterns. This flexibility positions it as an important player in processes such as cell cycle regulation and apoptosis.
Pathways
SRSF7 operates within the general mRNA processing pathway and plays a part in the spliceosome pathway. SRSF7 interacts with other splicing factors like SRSF1 which promotes its functional diversity. These proteins collectively enable precise and correct splicing of mRNA which is critical in maintaining cellular homeostasis and responding to physiological changes.
Abnormalities in SRSF7 expression or function can relate to cancer and neurodegenerative disorders. Dysregulation of mRNA splicing where SRSF7 plays a role can drive oncogenic transformations in cells linking it to various forms of cancer. Also SRSF7 and splicing-related proteins such as hnRNPs are observed in dysfunctional states within neurodegenerative conditions suggesting splicing alterations contribute to disease pathogenesis. Understanding SRSF7's role allows for better comprehension of these disorders and potential therapeutic strategies.