Abcam, ab137565, Anti-CREB3L1/OASIS antibody

Size: 100µL
Rabbit Polyclonal CREB3L1/OASIS antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Keep as concentrated solution.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 10% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CREB3L1 also known as OASIS is a transcription factor with a significant role in various cellular functions. It belongs to the CREB/ATF family and has a molecular mass of approximately 55 kDa. This protein is mainly expressed in the endoplasmic reticulum (ER) of astrocytes bone cells and certain cancerous cells. CREB3L1 regulates gene expression in response to stress conditions related to the ER making it a focal point of interest in cellular stress response studies.
Biological function summary
CREB3L1 is involved in the regulation of unfolded protein response (UPR). It activates genes responsible for protein folding processing and secretion ensuring proper cellular function. CREB3L1 or OASIS generally does not form complexes but operates predominantly on its own. It serves as a bridge between stress signals received by the ER and the transcriptional machinery of the nucleus thereby playing a critical role in maintaining cellular homeostasis.
Pathways
This transcription factor integrates signals within the unfolded protein response and bone metabolism pathways. CREB3L1 regulates the transcription of genes involved in ER stress response linking it to key proteins such as BiP and CHOP. Additionally CREB3L1 influences osteocalcin transcription tying it to bone formation and matrix production pathways. It directly affects cellular adaptation by controlling gene expression related to ER stress and osteogenesis.
CREB3L1 links closely to osteogenesis imperfecta and certain aspects of glioblastoma. Its regulatory function in osteocalcin expression connects it with bone fragility conditions necessitating in-depth research into CREB3L1-related pathways for potential therapeutic targets. In glioblastoma CREB3L1 expression correlates with tumor cell response to stress making it an essential protein for understanding the ER stress-related mechanisms in cancer progression. Connections with proteins like osteocalcin in bone disorders and BiP in stress responses highlight its importance in disease contexts.