Abcam, ab137619, Anti-ERK8 antibody

Size: 100µL
Rabbit Polyclonal ERK8 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MAPK15 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MAPK15 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q8TD08

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ERK8 also known as MAPK15 is a serine/threonine kinase with a molecular weight of approximately 49 kDa. It has an important role in cellular signaling pathways. This protein is involved in the regulation of several cellular processes including growth proliferation and survival. ERK8 is expressed in various tissues with notable expression in the brain lung and liver. Due to its broad expression profile it holds importance in understanding diverse physiological and pathological contexts.
Biological function summary
ERK8 engages in the regulation of cellular processes by modulating the activity of downstream targets. It is part of the Mitogen-Activated Protein Kinase (MAPK) family which typically functions in concert with other proteins to form signaling complexes. These complexes carry out phosphorylation events that are important for signaling transduction. ERK8 affects cell motility cytoskeletal rearrangements and transcriptional regulation impacting processes critical for cellular homeostasis and response to stress.
Pathways
ERK8 is involved in signaling pathways including the MAPK/ERK pathway and the PI3K/AKT pathway. Within these pathways ERK8 interacts closely with proteins such as RAF and MEK facilitating the transmission of extracellular signals to intracellular responses. Its role in the MAPK/ERK pathway is particularly significant given the pathway's influence on cellular proliferation and differentiation. ERK8's interaction with these pathways emphasizes its contribution to controlling cellular responses and adapting to environmental changes.
ERK8's functions relate to cancer and metabolic disorders. Its aberrant activity is associated with tumor progression as it can influence processes like cell proliferation and evasion of apoptosis. In the context of cancer ERK8 can interact with proteins like c-Jun a component of the AP-1 transcription factor complex to promote oncogenic transformations. Additionally ERK8 is implicated in metabolic disorders through its role in regulating glucose metabolism and insulin signaling making it a potential target for therapeutic intervention in diseases like diabetes.