Abcam, ab137691, Anti-p40 antibody

Size: 100µL
Rabbit Polyclonal p40 antibody. Suitable for IHC-P, WB, ICC/IF, IP and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RABEPK aa 150 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RABEPK aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q7Z6M1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The p40 protein also known as IL-12/IL-23 p40 subunit possesses a molecular mass of approximately 40 kDa. Scientists often detect p40 in immune cells such as dendritic cells and macrophages. This subunit exists as part of two heterodimeric cytokines IL-12 and IL-23 making it an important component to study in both health and disease conditions. It plays a significant role in mediating immune responses which makes it a vital target for research into immune system functioning.
Biological function summary
The p40 subunit forms part of the heterodimer complexes IL-12 and IL-23 which have different roles in the immune response. IL-12 which includes the p35 subunit alongside p40 is key for the differentiation of naive T cells into Th1 cells. This action leads to enhancement of the cellular immune response. In contrast the combination of p40 with p19 forms IL-23 which supports the survival and proliferation of Th17 cells playing a unique role in maintaining tissue integrity and combating extracellular pathogens.
Pathways
The p40 protein interacts significantly in the IL-12 and IL-23 signaling pathways which are essential for immune regulation and response. In these pathways IL-12 and IL-23 bind to their respective receptors leading to downstream effects that encourage the activation and differentiation of T cells. The signaling pathways involve other proteins such as STAT4 important for IL-12-dependent responses and STAT3 which is important for IL-23-mediated pathways. These interactions show how p40 contributes to complex and critical immune network regulation.
The p40 protein features prominently in autoimmune diseases and chronic inflammatory conditions. Researchers have linked aberrant production of IL-12 and IL-23 to conditions like psoriasis and inflammatory bowel disease. Elevated levels of p40 often p40-positive can align with disease states wherein the immune system mistakenly attacks the body’s own cells. This association with disease processes makes p40 a target for therapies aiming to modulate immune response. In the case of disorders proteins such as IL-23 and its receptor are involved alongside p40 further emphasizing its key role in pathological immune responses.